炎症和抗炎治疗在干眼症中的作用。
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca.
作者信息
Gumus Koray, Cavanagh Dwight H
机构信息
Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey.
出版信息
Clin Ophthalmol. 2009;3:57-67. Epub 2009 Jun 2.
Abstract
PURPOSE
To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories.
METHODS
A comprehensive literature survey.
RESULTS AND CONCLUSION
Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.
摘要
目的
回顾并整合近期在确定炎症在干眼症发病机制中的作用以及更新的抗炎理论的生物学原理和实际临床方面的进展。
方法
全面的文献调查。
结果与结论
干燥性角结膜炎（KCS）是一种多因素的复杂疾病，其中眼表炎症起核心作用。特定CD4-T细胞途径的鉴定以及最近对α- fodrin靶向作用的认识提示了新的治疗方向，如抗CD4单克隆抗体、全身应用亚油酸和γ-亚麻酸以及ω-6必需脂肪酸。用无防腐剂的湿润剂替代泪液量以及标准的典型抗炎皮质类固醇和/或环孢素A仍然是目前KCS传统治疗的核心。
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