不明原因不孕症中的地塞米松。

Dexamethasone in unexplained infertility.

作者信息

Moradan Sanam, Ghorbani Raheb

机构信息

Department of Obstetrics and Gynecology, Amir Hospital, Semnan, Iran.

出版信息

Saudi Med J. 2009 Aug;30(8):1034-6.

PMID:19668883

Abstract

OBJECTIVE

To determine if dexamethasone could be a suitable option in the treatment of patients with unexplained infertility.

METHODS

This study was carried out in the Obstetrics Department of Amir University Hospital, Semnan, Iran, from April 2001 to May 2008. One hundred and twenty-four cases of unexplained infertility that underwent ovulation induction and intrauterine insemination (IUI) (only one cycle) were evaluated, and divided into 2 groups. Sixteen cases were excluded, as they were unresponsive to the induction ovulation regimen. Group I (n=42) received clomiphene citrate (CC) + dexamethasone, and the control group (group II, n=66) received CC alone. These groups were the same in age, duration of infertility, and body mass index. The clinical pregnancy rates were evaluated in 2 groups by using statistical tests.

RESULTS

The clinical pregnancy rate was 21.4% in group I, and 4.5% in group II. There was a significant statistical difference between the groups (relative risk=4.71, 95% confidence interval=1.35-16.42, p=0.0085).

CONCLUSION

The pregnancy rate in women with unexplained infertility that underwent ovulation induction with CC + dexamethasone + IUI was significantly higher than those who underwent ovulation induction with CC alone + IUI.

摘要

目的

确定地塞米松是否为治疗不明原因不孕症患者的合适选择。

方法

本研究于2001年4月至2008年5月在伊朗塞姆南阿米尔大学医院妇产科进行。对124例接受排卵诱导和宫内人工授精（IUI）（仅一个周期）的不明原因不孕症患者进行评估，并分为2组。16例患者因对排卵诱导方案无反应而被排除。第一组（n = 42）接受枸橼酸氯米芬（CC）+地塞米松，对照组（第二组，n = 66）仅接受CC。两组在年龄、不孕持续时间和体重指数方面相同。采用统计学检验评估两组的临床妊娠率。