Fonseca Nilson Lopes da, Lucci Lucia Miriam Dumont, Cha Sung Bok, Rossetti Claudia, Rehder José Ricardo Carvalho Lima
Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Arq Bras Oftalmol. 2009 May-Jun;72(3):390-3. doi: 10.1590/s0004-27492009000300022.
Metastasis confined to eyelids are rare, representing less than 1% of malignant eyelid lesions. More than 50% of all eyelid metastasis are reported to have the breast as the most common primary origin. Two cases of metastatic eyelid disease associated with primary breast carcinoma are described. These lesions were the first sign of metastatic systemic disease. Case 1: An 80-year old woman with no significant ophthalmological history complaining of a discrete painless lesion in the left upper eyelid. She had been diagnosed 10 years before as infiltrated ductal carcinoma of right mammary gland with no reference of metastatic disease. Case 2: A 77-year old woman who attends our ophthalmology service came complaining of a four-month history of a painless swelling and erythema of right lower eyelid. The past medical history was significant for infiltrated ductal carcinoma on right mammary gland 2 years before the ocular manifestation. Breast carcinoma is notorious for its presentation diversity. Metastatic disease should be considered as differential diagnosis of eyelid lesions. Although rare, these lesions can be an initial sign of systemic malignancy.
局限于眼睑的转移瘤很少见，占恶性眼睑病变的比例不到1%。据报道，所有眼睑转移瘤中超过50%的原发灶最常见于乳腺。本文描述了2例与原发性乳腺癌相关的转移性眼睑疾病病例。这些病变是转移性全身疾病的首发症状。病例1：一名80岁女性，无明显眼科病史，主诉左上眼睑有一个孤立的无痛性病变。她10年前被诊断为右乳腺浸润性导管癌，当时未提及有转移疾病。病例2：一名77岁女性前来我们的眼科门诊就诊，主诉右下眼睑无痛性肿胀和红斑4个月。既往病史显示，眼部症状出现前2年，她被诊断为右乳腺浸润性导管癌。乳腺癌以其表现的多样性而闻名。转移性疾病应被视为眼睑病变的鉴别诊断。虽然罕见，但这些病变可能是全身恶性肿瘤的初始症状。
