Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, Verona, 37134, Italy,
Hepatol Int. 2008 Sep;2(3):335-40. doi: 10.1007/s12072-008-9076-z. Epub 2008 May 8.
Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.
越来越多的证据表明，铁过载是慢性丙型肝炎病毒（HCV）感染的常见发现，在该病的病理生理学中起着重要作用。本文综述了铁过载诱导肝损伤的机制，以及通过放血去除铁对慢性 HCV 感染患者的生化和组织学结果的益处。最后，我们重点讨论了铁减少对干扰素抗病毒治疗反应率的影响。
