Lagarde M, Dechavanne M
Biomedicine. 1977 Apr;27(3):110-2.
Cyclic AMP first decreased in wahed platelets after the addition of 0.1 IU thrombin/ml and then increased progressively. Platelets pre-incubated with acetylsalicylic acid showed only a decrease of cyclic AMP upon addition of thrombin. Furthermore, two patients with defective prostaglandin synthesis had always reduced cyclic AMP whether their platelets were pre-incubated with acetylsalicylic acid or not. Thus, if prostaglandin synthesis is inhibited the level of cyclic AMP decreased and did not increase with time.
加入每毫升0.1国际单位凝血酶后，洗涤过的血小板中的环磷酸腺苷（cAMP）首先减少，然后逐渐增加。预先用乙酰水杨酸孵育的血小板在加入凝血酶后仅显示环磷酸腺苷减少。此外，两名前列腺素合成缺陷的患者，无论其血小板是否预先用乙酰水杨酸孵育，其环磷酸腺苷水平总是降低。因此，如果前列腺素合成受到抑制，环磷酸腺苷水平会降低且不会随时间增加。
