Ferm V H, Hanlon D P, Willhite C C, Choy W N, Book S A
Department of Anatomy, Dartmouth Medical School, Hanover, New Hampshire 03756.
Reprod Toxicol. 1990;4(3):183-90. doi: 10.1016/0890-6238(90)90057-3.
Pregnant hamsters were treated with selenite, selenate, and selenomethionine during the critical stages of embryogenesis. The dosing regimens were oral, intravenous, and osmotic minipump infusion. Malformations, mainly encephaloceles, were noted with oral and intravenous selenite and selenate but were associated with maternal toxicity manifested by inanition and weight loss. Fetal body weights and lengths were reduced in a dose-dependent manner with the inorganic forms. Single oral doses of selenomethionine above 77 mumol/kg induced similar malformations but not when the dose was delivered orally over four days nor by minipump over several days. Fetal body weights and lengths were decreased by selenomethionine in a dose-dependent manner. Maternal toxicity was pronounced with the higher doses of selenomethionine. Assigning a specific teratogenic effect to selenium is confounded by maternal toxicity.
在胚胎发育的关键阶段，给怀孕的仓鼠分别用亚硒酸盐、硒酸盐和硒代蛋氨酸进行处理。给药方案包括口服、静脉注射和渗透微型泵输注。口服和静脉注射亚硒酸盐和硒酸盐后发现有畸形，主要是脑膨出，但这与以食欲不振和体重减轻为表现的母体毒性有关。无机形式的硒会使胎儿体重和身长呈剂量依赖性降低。单次口服剂量高于77 μmol/kg的硒代蛋氨酸会诱发类似的畸形，但当剂量在四天内口服给药或通过微型泵在数天内给药时则不会。硒代蛋氨酸会使胎儿体重和身长呈剂量依赖性下降。较高剂量的硒代蛋氨酸会导致明显的母体毒性。母体毒性使得难以确定硒是否具有特定的致畸作用。
