Lim Andrew S, Moro Elena, Lozano Andres M, Hamani Clement, Dostrovsky Jonathan O, Hutchison William D, Lang Anthony E, Wennberg Richard A, Murray Brian J
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ann Neurol. 2009 Jul;66(1):110-4. doi: 10.1002/ana.21631.
Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM-promoting and REM-inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS "off" and DBS "on" states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114.
动物研究表明，快速眼动（REM）睡眠受脑桥中脑被盖区中促进REM和抑制REM的核团相互作用的调控。有人提出脚桥核具有促进REM的作用。我们使用多导睡眠图对5例接受单侧脚桥核深部脑刺激（DBS）的帕金森病患者的睡眠情况进行了研究。我们发现，在DBS“关”和DBS“开”两种状态之间，夜间REM睡眠几乎增加了一倍，而其他睡眠状态没有显著变化。这是首次证明DBS可选择性调节人类睡眠，并且支持脚桥核区域在调节人类REM睡眠中起重要作用。《神经病学纪事》2009年；66:110 - 114。
