Kozak Monika, Kołodziej-Sobocińska Marta
Instytut Parazytologii im. Witolda Stefańskiego PAN, ul. Twarda 51/55, 00-818 Warszawa.
Wiad Parazytol. 2009;55(2):147-56.
Helminth infections are an important health problem for both humans and animals worldwide. The most sought for prophylactic strategy is vaccination due to the increasing incidence of anthelminthic resistance with little progress towards the discovery of novel drugs. However, the development of efficient anti-parasitic vaccines was proven to be a far greater challenge than in the case of bacteria or viruses. This is partly a result of the complex immunological interactions occurring during helminth infections, which are not yet fully understood, especially regarding the immune mechanisms conveying protection. Another problem is progressing from the research phase of vaccine development to commercial production and marketing. The advances made so far in developing efficient vaccines against helminth vary among the different classes, with a wide spectrum of both native and recombinant vaccine candidates. This review aims at presenting the current status and most important achievements in the field of helminth vaccine development, as well as the main obstacles and difficulties standing in the way of progress and practical applications.
蠕虫感染是全球人类和动物面临的一个重要健康问题。由于抗蠕虫药物耐药性的发生率不断上升，而新型药物的研发进展甚微，因此最受关注的预防策略是疫苗接种。然而，事实证明，开发高效的抗寄生虫疫苗比开发针对细菌或病毒的疫苗面临更大的挑战。部分原因是蠕虫感染期间发生的复杂免疫相互作用尚未完全了解，尤其是关于提供保护的免疫机制。另一个问题是从疫苗研发阶段进入商业生产和销售阶段。到目前为止，针对不同类别的蠕虫开发高效疫苗所取得的进展各不相同，有各种各样的天然和重组候选疫苗。这篇综述旨在介绍蠕虫疫苗研发领域的现状和最重要的成就，以及阻碍进展和实际应用的主要障碍和困难。
