Borovkova N Iu
Klin Med (Mosk). 2009;87(6):19-22.
Monitoring arterial pressure (AP) was used to evaluate its daily dynamics in 136 patients with the hypertensive form of chronic glomerulonephritis (CgN) and preserved renal function and in 49 with essential arterial hypertension (EAH). Diagnosis of CGN was verified by the results of clinical, laboratory, and instrumental studies as well as morphological examination of nephrobiopsies. Diurnal AP dynamics was evaluated from the analysis of mean systolic, diastolic, and pulse pressure, their variability, loading time, and daily AP rhythm. It was shown that daily AP dynamics in patients with hypertensive CGN is characterized by high "pressure load" both in daytime and at night. Their daily AP rhythm was much more disturbed than in EAH patients. The normal fall of night AP in these groups occurred in 20 and 40% of the cases respectively and its inadequate decrease in 53 and 39%. Night-time hypertension was documented in 27 vs 9% of the cases. Disturbances of daily AP rhythm in patients with hypertensive CGN were associated with lower pulse pressure than in EAH patients, greater variability of diastolic AP at night, and smaller increase of systolic AP in the morning.
对136例慢性肾小球肾炎（CgN）高血压型且肾功能尚存的患者以及49例原发性高血压（EAH）患者，采用监测动脉压（AP）的方法评估其每日动态变化。慢性肾小球肾炎的诊断通过临床、实验室、仪器检查结果以及肾活检的形态学检查得以证实。通过分析平均收缩压、舒张压和脉压、它们的变异性、负荷时间以及每日动脉压节律来评估日间动脉压动态变化。结果显示，高血压型慢性肾小球肾炎患者的每日动脉压动态变化特点是白天和夜间均存在高“压力负荷”。与原发性高血压患者相比，他们的每日动脉压节律紊乱得多。这些组中夜间动脉压正常下降分别出现在20%和40%的病例中，而下降不足分别出现在53%和39%的病例中。夜间高血压在27%的病例中被记录，而原发性高血压患者中为9%。高血压型慢性肾小球肾炎患者的每日动脉压节律紊乱与脉压低于原发性高血压患者、夜间舒张压变异性更大以及早晨收缩压升高幅度较小有关。
