Department of Biomedical Sciences, Centre for Healthy Ageing, University of Copenhagen, DK-2200, Copenhagen N, Denmark.
Pediatr Diabetes. 2010 May;11(3):195-202. doi: 10.1111/j.1399-5448.2009.00556.x. Epub 2009 Aug 4.
Biomarkers of metabolism and inflammation may predict children with increased diabetes risk.
To study plasma adiponectin, leptin, IL-8, and hepatocyte growth factor (HGF) in childhood and their independent associations with insulin insensitivity, cross-sectional and in 6-yr prospective.
Danish 8- to 10-yr-olds and 14- to 16-yr-olds from the European Youth Heart Studies I and II.
Cross-sectional (n = 386) and prospective (n = 246) linear regressions of baseline concentrations of plasma biomarkers and insulin insensitivity at baseline and 6 yr later. Adjustments were made at four progressive steps for sex, sexual maturity, body mass index (BMI), other biomarkers, physical activity, and school location as well as baseline insulin insensitivity in prospective analyses. Insulin insensitivity was measured using homeostasis model assessment standardized to the sample mean [homoestasis model assessment (HOMA) Z-scores]. Plasma biomarkers were quantified using solid-phase protein immunoassays. Overweight was defined as the highest BMI tertile.
Among overweight but not lean children at baseline, one SD difference in baseline plasma adiponectin was associated with -0.41 SD difference in HOMA Z-scores 6 yr later (p = 0.006). At baseline, one SD difference in plasma leptin was associated with 0.36 SD difference in HOMA Z-scores (p =< 0.0001) among 8- to 10-yr-olds, but a prospective association was not found.
We found a direct relationship between childhood hypo-adiponectinaemia and insulin insensitivity in adolescence. This association was stronger for overweight than for normal weight children. Hyper-leptinaemia was associated with concurrent insulin insensitivity at baseline but not 6 yr later.
代谢和炎症的生物标志物可以预测儿童糖尿病风险增加。
研究儿童血浆脂联素、瘦素、白细胞介素-8 和肝细胞生长因子 (HGF)，及其与胰岛素敏感性、横断面和 6 年前瞻性的独立关系。
来自欧洲青年心脏研究 I 和 II 的丹麦 8-10 岁和 14-16 岁儿童。
采用线性回归方法对基线血浆生物标志物浓度和基线及 6 年后胰岛素敏感性进行横断面（n=386）和前瞻性（n=246）分析。在四个渐进步骤中进行调整，包括性别、性成熟度、体重指数（BMI）、其他生物标志物、体力活动和学校位置，以及前瞻性分析中的基线胰岛素敏感性。胰岛素敏感性采用基于样本均值的稳态模型评估标准化值[稳态模型评估（HOMA）Z 评分]进行测量。血浆生物标志物采用固相蛋白免疫分析法进行定量。超重定义为 BMI 最高三分位。
在基线超重但不肥胖的儿童中，基线时血浆脂联素的标准差差异与 6 年后 HOMA Z 评分的 -0.41 标准差差异相关（p=0.006）。在 8-10 岁儿童中，基线时血浆瘦素的标准差差异与 HOMA Z 评分的 0.36 标准差差异相关（p<0.0001），但未发现前瞻性关联。
我们发现儿童时期低脂联素血症与青春期胰岛素敏感性之间存在直接关系。这种关联在超重儿童中比在正常体重儿童中更强。高瘦素血症与基线时的胰岛素敏感性相关，但与 6 年后的胰岛素敏感性无关。
