Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China.
Nephron Clin Pract. 2009;113(3):c155-61. doi: 10.1159/000232596. Epub 2009 Aug 12.
Renal interstitial foam cells (FCs) are occasionally observed in various renal diseases. The goal of the present study was to determine the relationship between the formation of renal interstitial FCs and the degree of proteinuria and hyperlipidemia, as well as the progression of these diseases.
125 patients with Alport syndrome (AS), 192 patients with idiopathic membranous nephropathy (IMN), 388 patients with IgA nephropathy (IgAN), and 137 patients with focal segmental glomerulosclerosis (FSGS) were investigated retrospectively.
FCs were observed in various glomerular diseases. The frequency of interstitial FCs was 64.8% in AS, 21.4% in MN, 12.4% in IgAN, and 36.5% in FSGS. Regardless of the pathologic diagnosis of the glomerular disease, segmental glomerular sclerosis occurred more frequently in patients with FCs than in patients without FCs. In the AS or IgAN group, interstitial fibrosis was more severe, and levels of proteinuria and serum lipids were significantly higher in FC-positive patients than in patients without FCs.
FC formation in renal interstitium is associated with the degree of proteinuria and hyperlipidemia in patients with AS and IgAN. The presence of FCs in renal interstitium may contribute to the progression of glomerular diseases.
肾间质泡沫细胞（FC）偶尔可见于各种肾脏疾病。本研究旨在探讨肾间质 FC 的形成与蛋白尿和高脂血症的严重程度以及这些疾病的进展之间的关系。
回顾性分析 125 例 Alport 综合征（AS）患者、192 例特发性膜性肾病（IMN）患者、388 例 IgA 肾病（IgAN）患者和 137 例局灶节段性肾小球硬化症（FSGS）患者。
FC 可见于各种肾小球疾病。AS 患者中 FC 的频率为 64.8%，MN 患者中为 21.4%，IgAN 患者中为 12.4%，FSGS 患者中为 36.5%。无论肾小球疾病的病理诊断如何，FC 阳性患者的局灶性肾小球硬化发生率均高于 FC 阴性患者。在 AS 或 IgAN 组中，间质纤维化更严重，FC 阳性患者的蛋白尿和血清脂质水平显著高于 FC 阴性患者。
AS 和 IgAN 患者肾间质中 FC 的形成与蛋白尿和高脂血症的严重程度有关。肾间质中 FC 的存在可能有助于肾小球疾病的进展。
