Zhu S G, McGeer E G, McGeer P L
Department of Psychiatry, University of British Columbia, Vancouver.
Exp Neurol. 1990 Jan;107(1):106-9. doi: 10.1016/0014-4886(90)90067-3.
gamma-Glutamyltransferase (GGT; gamma-glutamyl transpeptidase) was measured in the neostriata of rats 5-7 days after local injections of 0-150 nmol of quinolinic acid. In contrast to the high levels seen in studies on the caudate in a few Huntington's disease cases, GGT activity showed no significant relation to the amount of quinolinic acid injected or to the extent of neuronal loss, as indicated by assays of choline acetyltransferase and glutamate decarboxylase on the same striatal homogenates. The chronicity of the degenerative disease, contrasted with the acuteness of the lesion, may explain the difference.
在大鼠局部注射0 - 150 nmol喹啉酸5 - 7天后，检测其新纹状体中的γ-谷氨酰转移酶（GGT；γ-谷氨酰转肽酶）。与少数亨廷顿病病例尾状核研究中所见的高水平不同，GGT活性与注射的喹啉酸量或神经元损失程度无显著关系，同一纹状体匀浆中胆碱乙酰转移酶和谷氨酸脱羧酶的检测结果表明了这一点。退行性疾病的慢性与损伤的急性形成对比，这可能解释了这种差异。
