Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Diabetes Care. 2009 Nov;32(11):2087-93. doi: 10.2337/dc09-0380. Epub 2009 Aug 12.
To examine sex-specific black/white differences in lipoprotein profile and the role of visceral adiposity and to assess the relationship between insulin sensitivity and lipoprotein profiles in each group.
Fasting lipoprotein particle size and concentration and visceral adipose tissue (VAT) were determined in 226 children (117 black, 101 male) aged 8 to <18 years. The relationship between lipoproteins and insulin sensitivity was evaluated in a subset of 194 children (100 black, 88 male) who underwent a hyperinsulinemic-euglycemic clamp.
Black male children had smaller VLDL and black female children had larger HDL size than their white counterparts. Overall, blacks had larger LDL size with no sex-specific race differences. After adjusting for VAT and sex, only VLDL size and concentrations remained significantly favorable in blacks. Analysis of lipoprotein particle size and concentration across insulin sensitivity quartiles revealed that in both racial groups, the most insulin-resistant children had higher concentrations of small dense LDL, small HDL, and large VLDL and smaller LDL and HDL sizes than their more insulin-sensitive counterparts.
The previously reported favorable lipoprotein profiles in black versus white children is partly due to race differences in VAT. In both groups, however, the most insulin-resistant youths have a high-risk atherogenic profile of small dense LDL, small HDL, and large VLDL, akin to the atherogenic lipoprotein pattern in adults with coronary artery disease.
研究脂蛋白谱中性别特异性的黑/白差异，以及内脏脂肪堆积的作用，并评估各组中胰岛素敏感性与脂蛋白谱之间的关系。
在 226 名年龄为 8 至 <18 岁的儿童（117 名黑人，101 名男性）中，检测空腹脂蛋白颗粒大小和浓度以及内脏脂肪组织（VAT）。在接受高胰岛素-正常血糖钳夹试验的 194 名儿童（100 名黑人，88 名男性）亚组中，评估了脂蛋白与胰岛素敏感性之间的关系。
与白人相比，黑人男性儿童的 VLDL 更小，黑人女性儿童的 HDL 更大。总体而言，黑人的 LDL 更大，但没有性别特异性的种族差异。在调整了 VAT 和性别后，只有 VLDL 大小和浓度在黑人群体中仍然明显更好。对脂蛋白颗粒大小和浓度在胰岛素敏感性四分位数中的分析表明，在两个种族群体中，最胰岛素抵抗的儿童具有更高浓度的小而密 LDL、小而密 HDL 和大 VLDL，以及更小的 LDL 和 HDL 大小，与更胰岛素敏感的同龄人相比。
先前报道的黑人儿童与白人儿童相比具有更好的脂蛋白谱，部分原因是 VAT 存在种族差异。然而，在两组中，最胰岛素抵抗的青少年具有高风险的致动脉粥样硬化的小而密 LDL、小而密 HDL 和大 VLDL 特征，类似于患有冠心病的成年人心血管疾病的致动脉粥样硬化脂蛋白模式。
