Department of Medicine, Division of Dermatology, University of California at San Diego, La Jolla, California, USA.
J Leukoc Biol. 2009 Nov;86(5):1125-34. doi: 10.1189/jlb.0209103. Epub 2009 Aug 12.
Ethanol consumption is linked to a higher incidence of traumatic wounds and increases the risk for morbidity and mortality following surgical or traumatic injury. One of the most profound effects of acute ethanol exposure on wound healing occurs during the inflammatory response, and altered cytokine production is a primary component. Acute ethanol exposure also impairs the proliferative response during healing, causing delays in epithelial coverage, collagen synthesis, and blood vessel regrowth. The accumulated data support the paradigm that acute ethanol intoxication prior to injury significantly diminishes a patient's ability to heal efficiently.
乙醇摄入与创伤性伤口的发生率较高有关，并增加手术或创伤性损伤后发病和死亡的风险。急性乙醇暴露对伤口愈合影响最深远的之一发生在炎症反应期间，细胞因子产生的改变是主要组成部分。急性乙醇暴露还会损害愈合过程中的增殖反应，导致上皮覆盖、胶原合成和血管再生延迟。累积的数据支持这样一种观点，即在受伤前急性乙醇中毒会显著降低患者有效愈合的能力。
