哺乳期甲状腺功能亢进症的药物治疗。
Pharmacologic treatment of hyperthyroidism during lactation.
作者信息
Glatstein Miguel Marcelo, Garcia-Bournissen Facundo, Giglio Norberto, Finkelstein Yaron, Koren Gideon
出版信息
Can Fam Physician. 2009 Aug;55(8):797-8.
Abstract
QUESTION
I have a patient who has hyperthyroidism due to Graves disease. She was taking methimazole but discontinued when she found out she was pregnant. She is currently close to delivery and might require antithyroid therapy in the postpartum period. Can methimazole cross into human milk, and is breastfeeding safe for her infant?
ANSWER
The exposure of infants to methimazole or propylthiouracil through breast milk is minimal and not clinically significant. Women with hyperthyroidism using methimazole or propylthiouracil should not be discouraged from breastfeeding, as the benefits of breastfeeding largely outweigh the theoretical minimal risks.
摘要
问题
我有一位因格雷夫斯病患有甲状腺功能亢进症的患者。她一直在服用甲巯咪唑，但在发现自己怀孕后停药了。她目前已接近分娩，产后可能需要抗甲状腺治疗。甲巯咪唑会进入母乳吗？对她的婴儿进行母乳喂养安全吗？
答案
婴儿通过母乳接触甲巯咪唑或丙硫氧嘧啶的量极少，临床上无显著意义。患有甲状腺功能亢进症且正在使用甲巯咪唑或丙硫氧嘧啶的女性不应被劝阻进行母乳喂养，因为母乳喂养的益处远大于理论上极小的风险。
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