Layton Anita T, Layton Harold E, Dantzler William H, Pannabecker Thomas L
Department of Mathematics, Duke University, Durham, North Carolina, USA.
Physiology (Bethesda). 2009 Aug;24:250-6. doi: 10.1152/physiol.00013.2009.
The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney's three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels.
哺乳动物肾脏的尿液浓缩机制是传统生理学中长久以来的谜团之一，在缺水期间，该机制能够产生比血浆浓度高得多的尿液。由于肾小管和血管在外髓质和内髓质中存在复杂的横向和轴向关系，只有从肾脏的三维功能结构及其对肾小管和血管间优先相互作用的影响方面，才能全面理解尿液浓缩机制。
