Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Am J Clin Oncol. 2010 Apr;33(2):125-7. doi: 10.1097/COC.0b013e31819791eb.
Microcystic adnexal carcinoma (MAC) is a very rare cancer of the skin. It has only been described previously in case reports and small retrospective series.
To analyze and summarize data from the National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) database regarding MAC.
The SEER 1973 to 2004 database was investigated, and patients with MAC were identified. A statistical analysis was performed.
Two hundred twenty-three patients were identified. Predominant site of disease was the head and neck skin (74%). There was only 1 case of recorded metastatic disease. Lymph nodes were pathologically involved in 1%. The 10-year overall survival was 86.4% (Standard Error [SE]: 3.3%). US census population-matched relative survival was 97.7% at 10 years (SE: 5.2%).
This study is limited by the retrospective nature of the SEER database.
MAC is locally invasive, and rarely metastasizes to lymph nodes. Overall and population-matched relative survival is excellent.
微囊性附属器癌（MAC）是一种非常罕见的皮肤癌。此前，仅在病例报告和小型回顾性研究中对其进行了描述。
分析和总结美国国家癌症研究所、监测、流行病学和最终结果（SEER）数据库中关于 MAC 的数据。
调查了 SEER 1973 年至 2004 年的数据库，并确定了 MAC 患者。进行了统计分析。
共确定了 223 例患者。疾病的主要部位是头颈部皮肤（74%）。仅记录到 1 例转移性疾病。淋巴结病理受累为 1%。10 年总生存率为 86.4%（标准误差[SE]：3.3%）。10 年时美国人口匹配的相对生存率为 97.7%（SE：5.2%）。
本研究受 SEER 数据库回顾性的限制。
MAC 具有局部侵袭性，很少转移到淋巴结。总体和人群匹配的相对生存率非常好。
