Coelho Sergio G, Choi Wonseon, Brenner Michaela, Miyamura Yoshinori, Yamaguchi Yuji, Wolber Rainer, Smuda Christoph, Batzer Jan, Kolbe Ludger, Ito Shosuke, Wakamatsu Kazumasa, Zmudzka Barbara Z, Beer Janusz Z, Miller Sharon A, Hearing Vincent J
Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
J Investig Dermatol Symp Proc. 2009 Aug;14(1):32-5. doi: 10.1038/jidsymp.2009.10.
The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 32-35; doi:10.1038/jidsymp.2009.10.
近年来，包括皮肤黑素瘤在内的皮肤癌发病率大幅上升，流行病学和实验室研究表明，紫外线辐射是导致这种增长的主要因素。紫外线损伤也是皮肤光老化的基础，而在具有较高固有色素沉着水平的皮肤中，紫外线的这些有害影响在一定程度上可以得到预防。我们回顾了近年来我们所做的关于人体皮肤色素系统对紫外线照射的快速和长期反应的临床研究。《皮肤病学研究杂志》研讨会论文集（2009年）14卷，32 - 35页；doi:10.1038/jidsymp.2009.10
