Gütgemann Stefan, Frank Susanne, Strehl John, Schmidt-Wolf Ingo G H
Department of Internal Medicine I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Ger Med Sci. 2007 Sep 10;5:Doc07.
Until now, cytokine-induced killer (CIK) cells were assumed to be part of the type I natural killer T (NKT) cell population, but it was not yet investigated if this is correct.
For analysis, CIK cells were generated by various culture conditions. Human type I NKT cells express a T cell receptor (TCR) composed of an invariant V alpha 24-J alpha Q chain combined with one of several V beta chains. The V alpha 24 is a reliable marker for the presence of these TCRs.
While comparing cultures stimulated with different substances, we observed the lack of any V alpha 24 on the surface of CIK culture cells.
We conclude that CIK cells do not belong to the type I NKT cells.
到目前为止，细胞因子诱导的杀伤（CIK）细胞被认为是I型自然杀伤T（NKT）细胞群体的一部分，但这一观点是否正确尚未得到研究。
为了进行分析，通过各种培养条件生成CIK细胞。人类I型NKT细胞表达一种由不变的Vα24-JαQ链与几种Vβ链之一组合而成的T细胞受体（TCR）。Vα24是这些TCR存在的可靠标志物。
在比较用不同物质刺激的培养物时，我们观察到CIK培养细胞表面缺乏任何Vα24。
我们得出结论，CIK细胞不属于I型NKT细胞。
