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激素抵抗性前列腺癌的治疗算法:实用指南。

Treatment algorithm in hormone-resistant prostate cancer: Practical guidelines.

作者信息

Khochikar Makarand V

机构信息

Department of Uro-oncology, Siddhi Vinayak Ganapati Cancer Hospital, Miraj, India.

出版信息

Indian J Urol. 2007 Jan;23(1):67-9. doi: 10.4103/0970-1591.30271.

DOI:10.4103/0970-1591.30271
PMID:19675767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2721501/
Abstract

Treatment of hormone-resistant prostate cancer can be a challenging situation. The first important step in treating this condition is to assess if one has achieved the castrate level or not. If the castrate levels are not achieved, attempt should be made to achieve so. If the castrate level is achieved, then androgen withdrawals may be of help. Supportive care, care of the clinical problems forms an integral part of the treatment. Cancer-specific chemotherapy is certainly an option in progressive disease.

摘要

激素抵抗性前列腺癌的治疗可能是一个具有挑战性的情况。治疗这种疾病的首要重要步骤是评估是否已达到去势水平。如果未达到去势水平,应尝试达到该水平。如果达到了去势水平,那么雄激素撤退可能会有所帮助。支持性护理,即对临床问题的护理,是治疗的一个组成部分。对于进展性疾病,癌症特异性化疗当然是一种选择。

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本文引用的文献

1
Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer.前列腺癌患者中,草药补充剂PC-SPES与己烯雌酚用于雄激素非依赖性前列腺癌的前瞻性、多中心、随机II期试验。
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Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583).单独使用抗雄激素药物或与酮康唑联合用于雄激素非依赖性前列腺癌患者:一项III期试验(CALGB 9583)。
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3
Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails.在雄激素去除疗法失败后,尼鲁米特作为前列腺癌的二线激素疗法。
J Urol. 2003 May;169(5):1742-4. doi: 10.1097/01.ju.0000057795.97626.66.
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Strontium-89 (Metastron) and the bisphosphonate olpadronate reduce the incidence of spinal cord compression in patients with hormone-refractory prostate cancer metastatic to the skeleton.锶-89(美他生)和双膦酸盐奥帕膦酸盐可降低激素难治性前列腺癌骨转移患者脊髓压迫的发生率。
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Erythropoietin in urologic oncology.泌尿外科肿瘤学中的促红细胞生成素
Eur Urol. 2001 Jan;39(1):1-8. doi: 10.1159/000052404.
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A comparison of adjuvant psychological therapy and supportive counselling in patients with cancer.
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7
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J Clin Oncol. 1997 Aug;15(8):2928-38. doi: 10.1200/JCO.1997.15.8.2928.
8
Ketoconazole retains activity in advanced prostate cancer patients with progression despite flutamide withdrawal.尽管停用氟他胺,酮康唑在疾病进展的晚期前列腺癌患者中仍保持活性。
J Urol. 1997 Apr;157(4):1204-7.
9
The antiandrogen withdrawal syndrome. Experience in a large cohort of unselected patients with advanced prostate cancer.抗雄激素撤药综合征。一大群未经选择的晚期前列腺癌患者的经验。
Cancer. 1995 Oct 15;76(8):1428-34. doi: 10.1002/1097-0142(19951015)76:8<1428::aid-cncr2820760820>3.0.co;2-t.
10
Importance of continued testicular suppression in hormone-refractory prostate cancer.持续抑制睾丸功能在激素难治性前列腺癌中的重要性。
J Clin Oncol. 1993 Nov;11(11):2167-72. doi: 10.1200/JCO.1993.11.11.2167.