Bural Gonca G, Torigian Drew A, Botvinick Elias, Houseni Mohamed, Basu Sandip, Chen Wengen, Alavi Abass
Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Hell J Nucl Med. 2009 May-Aug;12(2):123-8.
Our aim was to quantify changes in the inflammatory and calcific components of atherosclerosis in the aortic wall using fluoro-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (18)F-FDGPET and contrast enhanced computerized tomography (CECT) with increasing age. Twelve subjects, 8 men and 4 women aged from 21-80 years who had both (18)F-FDG-PET and CECT of the chest and abdomen were included in this study. Subjects were grouped into three according to age. (18)F-FDG uptake in four segments of the aorta was measured. Using CECT images, aortic segmental wall volumes were measured. Wall calcification volume in each aortic segment was also measured via adaptation of a coronary artery calcium-scoring program to the aorta. Calcification volumes were then subtracted from aortic wall volumes. Each net segmental aortic wall volume was then multiplied by the accompanying mean SUV of the segment to calculate global metabolic activity (GMA) for each aortic segment. Our results showed that in each aortic wall segment, mean SUV, wall volumes, wall calcification volumes, and GMA statistically significantly increased with age. In conclusion, (18)F-FDG uptake, wall volume, wall calcification volume, and GMA in the aorta increase with aging. The (18)F-FDG uptake represents the early inflammatory component of the atherosclerotic process, whereas calcification generally represents a later and irreversible stage of the disease. Measurement and combination of PET and CECT parameters to calculate GMA may allow for optimal morphologic and functional noninvasive quantitative assessment of global aortic atherosclerotic disease.
我们的目的是利用氟-18-2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（18F-FDG PET）和对比增强计算机断层扫描（CECT），量化随着年龄增长主动脉壁动脉粥样硬化炎症和钙化成分的变化。本研究纳入了12名年龄在21至80岁之间的受试者，其中8名男性和4名女性，他们均接受了胸部和腹部的18F-FDG PET和CECT检查。受试者按年龄分为三组。测量了主动脉四个节段的18F-FDG摄取量。利用CECT图像测量主动脉节段壁体积。还通过将冠状动脉钙化评分程序应用于主动脉来测量每个主动脉节段的壁钙化体积。然后从主动脉壁体积中减去钙化体积。然后将每个主动脉节段的净壁体积乘以该节段相应的平均SUV，以计算每个主动脉节段的整体代谢活性（GMA）。我们的结果表明，在每个主动脉壁节段中，平均SUV、壁体积、壁钙化体积和GMA均随年龄增长而在统计学上显著增加。总之，主动脉中18F-FDG摄取、壁体积、壁钙化体积和GMA随年龄增长而增加。18F-FDG摄取代表动脉粥样硬化过程的早期炎症成分，而钙化通常代表疾病的晚期且不可逆阶段。测量PET和CECT参数并结合计算GMA，可能有助于对整体主动脉粥样硬化疾病进行最佳的形态学和功能无创定量评估。
