儿茶酚结构对酪氨酸酶自杀失活的影响。

The influence of catechol structure on the suicide-inactivation of tyrosinase.

作者信息

Ramsden Christopher A, Stratford Michael R L, Riley Patrick A

机构信息

Lennard-Jones Laboratories, School of Physical and Geographical Sciences, Keele University, Staffordshire, ST5 5BG, UK.

出版信息

Org Biomol Chem. 2009 Sep 7;7(17):3388-90. doi: 10.1039/b910500j. Epub 2009 Jul 9.

DOI:10.1039/b910500j

PMID:19675891

Abstract

3,6-Difluorocatechol, which cannot act as a monooxygenase tyrosinase substrate, is an oxidase substrate, and, in contrast to other catechols, oxidation does not lead to suicide-inactivation, providing experimental evidence for an inactivation mechanism involving reductive elimination of Cu(0) from the active site.

摘要

3,6-二氟儿茶酚不能作为单加氧酶酪氨酸酶的底物，而是一种氧化酶底物，与其他儿茶酚不同，其氧化不会导致自杀失活，这为涉及从活性位点还原消除Cu(0)的失活机制提供了实验证据。