[爱泼斯坦-巴尔病毒致敏的人T淋巴细胞的细胞毒性。HLA抗原在病毒感染的靶细胞表面的作用]

[Cytotoxicity of human T-lymphocytes sensitized by Epstein-Barr virus. Role of HLA antigens at the surface of target cells infected by the virus].

作者信息

Tursz T, Fridman W H, Tsapis A, Senik A, Fellous M

出版信息

C R Acad Hebd Seances Acad Sci D. 1977 May 23;284(20):2063-6.

Abstract

Peripheral T-lymphocytes from patients with infectious mononucleosis are cytotoxic towards target cells from Epstein-Barr virus-genome carrying human lumphoblastoid lines. Thus, these T-cells appear to be sensitized to viral coded determinants. Daudi cells, that carry EBV-genome, but lack HLA antigens are resistant to specific cytolysis in this model. These results suggest direct HLA involvement in the target structure recognized by birus-sensitized cytolytic T-lymphocytes in human.

摘要

传染性单核细胞增多症患者的外周血T淋巴细胞对携带EB病毒基因组的人淋巴母细胞系的靶细胞具有细胞毒性。因此，这些T细胞似乎对病毒编码的决定簇敏感。在该模型中，携带EBV基因组但缺乏HLA抗原的Daudi细胞对特异性细胞溶解具有抗性。这些结果表明HLA直接参与了人类中病毒致敏的细胞毒性T淋巴细胞所识别的靶结构。

相似文献

1

[Cytotoxicity of human T-lymphocytes sensitized by Epstein-Barr virus. Role of HLA antigens at the surface of target cells infected by the virus].[爱泼斯坦-巴尔病毒致敏的人T淋巴细胞的细胞毒性。HLA抗原在病毒感染的靶细胞表面的作用]

C R Acad Hebd Seances Acad Sci D. 1977 May 23;284(20):2063-6.

2

Absence of allogeneic restriction in human T-cell-mediated cytotoxicity to Epstein-Barr virus-infected target cells. Demonstration of an HLA-linked control at the effector level.人类T细胞介导的对爱泼斯坦-巴尔病毒感染靶细胞的细胞毒性中同种异体限制的缺失。效应水平上HLA连锁控制的证明。

J Exp Med. 1979 Dec 1;150(6):1310-22. doi: 10.1084/jem.150.6.1310.

3

Cytotoxic effector cells specific for B Cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis.传染性单核细胞增多症患者体内存在针对爱泼斯坦-巴尔病毒转化的B细胞系的细胞毒性效应细胞。

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4

Cytotoxic effector cells from infectious mononucleosis patients in the acute phase do not specifically kill Epstein-Barr virus genome-carrying lymphoid cell lines.急性期传染性单核细胞增多症患者的细胞毒性效应细胞不会特异性杀伤携带爱泼斯坦-巴尔病毒基因组的淋巴母细胞系。

Infect Immun. 1982 Oct;38(1):251-9. doi: 10.1128/iai.38.1.251-259.1982.

5

Cell-mediated immunity against Epstein-Barr virus infected B lymphocytes.针对爱泼斯坦-巴尔病毒感染的B淋巴细胞的细胞介导免疫。

Springer Semin Immunopathol. 1982;5(1):63-73. doi: 10.1007/BF00201957.

6

Development of Epstein-Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis.急性传染性单核细胞增多症中爱泼斯坦-巴尔病毒特异性记忆性T细胞受体克隆型的发育

J Exp Med. 1996 Nov 1;184(5):1815-24. doi: 10.1084/jem.184.5.1815.

7

Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined membrane antigens. I. Reactivity in sera from normal persons and from patients with acute infectious mononucleosis.针对爱泼斯坦-巴尔病毒决定的膜抗原的抗体依赖性细胞毒性（ADCC）。I. 正常人及急性传染性单核细胞增多症患者血清中的反应性。

Clin Exp Immunol. 1976 Jul;25(1):1-5.

8

CD8+ T cell subsets of cytotoxic T lymphocytes induced by Epstein-Barr virus infection in infectious mononucleosis.传染性单核细胞增多症中由爱泼斯坦-巴尔病毒感染诱导的细胞毒性T淋巴细胞的CD8 + T细胞亚群

Tohoku J Exp Med. 1990 Nov;162(3):213-24. doi: 10.1620/tjem.162.213.

9

Absence of Epstein-Barr virus-specific, HLA class II-restricted CD4+ cytotoxic T lymphocytes in infectious mononucleosis.传染性单核细胞增多症中缺乏爱泼斯坦-巴尔病毒特异性、HLA-II类分子限制性CD4+细胞毒性T淋巴细胞

Clin Exp Immunol. 1990 Mar;79(3):409-15. doi: 10.1111/j.1365-2249.1990.tb08104.x.

10

Cytotoxic T cell recognition of Epstein-Barr virus-infected B cells. II. Blocking studies with monoclonal antibodies to HLA determinants.细胞毒性T细胞对爱泼斯坦-巴尔病毒感染的B细胞的识别。II. 针对HLA决定簇的单克隆抗体的阻断研究。

Eur J Immunol. 1981 Sep;11(9):694-9. doi: 10.1002/eji.1830110905.

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