新数据支持神经营养因子在关节炎中具有重要作用。
New data favouring that neurotrophins are of importance in arthritis.
作者信息
Forsgren Sture
出版信息
Arthritis Res Ther. 2009;11(4):122. doi: 10.1186/ar2754. Epub 2009 Jul 30.
Abstract
Neurotrophins are important in inflammation. In an article in Arthritis Research & Therapy, Barthel and collaborators give new information on the existence of neurotrophin production in the synovial tissue of arthritic joints. These findings, together with other recent findings, stress that neurotrophins should be considered important factors in arthritis. This is reinforced by the facts that they are also produced by articular chondrocytes and that receptors for these are present in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effects in arthritis.
摘要
神经营养因子在炎症中起着重要作用。在《关节炎研究与治疗》上发表的一篇文章中，巴特尔及其合作者提供了关于关节炎关节滑膜组织中神经营养因子产生情况的新信息。这些发现与其他近期研究结果共同强调，神经营养因子应被视为关节炎中的重要因素。关节软骨细胞也能产生神经营养因子，且滑膜组织和软骨细胞上存在其受体，这些事实进一步强化了这一观点。神经营养因子在关节中的重要性应得到进一步研究，包括对干扰其在关节炎中作用效果的研究。
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2
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3
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4
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