设计上无催化活性。
Catalytically incompetent by design.
出版信息
Structure. 2009 Aug 12;17(8):1038-40. doi: 10.1016/j.str.2009.07.004.
Abstract
Sondermann and colleagues have characterized FimX, a protein with degenerate GGDEF and EAL domains. The study confirms the expected domain folds lacking conserved catalytic residues for c-di-GMP synthesis/degradation, and also defines domain arrangements, providing insight to regulatory mechanisms.
摘要
松德曼（Sondermann）及其同事对具有退化 GGDEF 和 EAL 结构域的 FimX 蛋白进行了特征描述。该研究证实了预期的结构域折叠，缺乏 c-di-GMP 合成/降解的保守催化残基，同时还定义了结构域排列，为调控机制提供了深入了解。
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