利用新工具确定与冠状动脉疾病相关的风险性状的遗传基础：撒丁岛研究
Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
作者信息
Strait James B, Uda Manuela, Lakatta Edward G, Najjar Samer S
机构信息
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
出版信息
Trends Cardiovasc Med. 2009 Apr;19(3):69-75. doi: 10.1016/j.tcm.2009.05.001.
Abstract
Genomewide association studies are increasingly being applied to search for novel genes that might underlie cardiovascular diseases. In this article, we briefly review the principles that underlie modern genetic analyses and provide several illustrations from the SardiNIA study of genomewide association studies for cardiovascular risk factor traits.
摘要
全基因组关联研究正越来越多地被用于寻找可能是心血管疾病潜在病因的新基因。在本文中，我们简要回顾现代基因分析所依据的原理，并提供撒丁岛人心血管疾病风险因素性状全基因组关联研究（SardiNIA研究）中的几个例证。
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