Yu Binglan, Bloch Kenneth D, Zapol Warren M
Anesthesia Center for Critical Care Research of the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Trends Cardiovasc Med. 2009 Apr;19(3):103-7. doi: 10.1016/j.tcm.2009.06.004.
Hemoglobin-based oxygen carriers (HBOCs) have been studied for decades as red blood cell substitutes. Profound vasoconstrictor effects have limited the clinical utility of HBOCs and are attributable to avid scavenging of nitric oxide (NO). Inhaling NO can charge the body's stores of NO metabolites without producing hypotension and can prevent systemic hypertension induced when HBOCs are subsequently infused. Concurrent breathing of low NO doses can prevent pulmonary vasoconstriction after HBOC infusion without augmenting plasma methemoglobinemia.
基于血红蛋白的氧载体(HBOCs)作为红细胞替代物已被研究了数十年。强烈的血管收缩作用限制了HBOCs的临床应用,这归因于对一氧化氮(NO)的大量清除。吸入NO可以补充体内的NO代谢产物储备而不引起低血压,并且可以预防随后输注HBOCs时诱发的全身性高血压。同时吸入低剂量的NO可以预防HBOC输注后的肺血管收缩,而不会增加血浆高铁血红蛋白血症。