Ashby J P, MacPherson J N, Strong J A
Clin Endocrinol (Oxf). 1977 Aug;7(2):167-70. doi: 10.1111/j.1365-2265.1977.tb01309.x.
The effect of thyroid status on renal adenosine 3', 5'-cyclic monophosphate (cyclic AMP) metabolism was assessed by measuring the increase in plasma cyclic AMP concentration following the intravenous administration of parathyroid hormone (PTH) to five hypothyroid and six hyperthyroid patients and seven euthyroid control subjects. PTH caused a rapid, transient increase in the concentration of plasma cyclic AMP which was similar in magnitude and time course in the euthyroid and hyperthyroid groups, but reduced in magnitude in the hypothyroid patients. The magnitude of the plasma cyclic AMP response to PTH was positively related to the free thyroxine index. The results suggest that the development of hypothyroidism may impair the renal response to PTH by affecting the turnover of cyclic AMP in the renal cortex.
通过测量静脉注射甲状旁腺激素（PTH）后五名甲状腺功能减退患者、六名甲状腺功能亢进患者和七名甲状腺功能正常对照者血浆环磷腺苷（cAMP）浓度的升高，评估甲状腺状态对肾腺苷3'，5'-环磷酸（环磷腺苷）代谢的影响。PTH导致血浆环磷腺苷浓度迅速、短暂升高，在甲状腺功能正常和甲状腺功能亢进组中，其幅度和时间过程相似，但在甲状腺功能减退患者中幅度降低。血浆环磷腺苷对PTH反应的幅度与游离甲状腺素指数呈正相关。结果表明，甲状腺功能减退的发生可能通过影响肾皮质中环磷腺苷的周转而损害肾脏对PTH的反应。
