Central Science Laboratory, Sand Hutton, York Y041 1LZ, UK.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Apr;26(4):574-82. doi: 10.1080/02652030802477947.
This work investigated if overall migration test procedures could also be used to test for the migration of specific substances from plastics. The overall migration test procedure used was the evaporative gravimetric method used with volatile food simulants. Thirty food-contact substances (additives and monomers) were tested for their chemical stability and volatile loss during the heated evaporation stage of the overall migration procedure. Eighteen of the 30 were determined in an acceptable yield. It is concluded that in the list of approximately 620 European Union substances that have specific migration limits of 5 mg kg(-1) or higher, and based on considerations of stability and volatility, more than half could be amenable to control using overall migration methodology. This is particularly the case for inert plastics with low intrinsic overall migration values of oligomers. This means that based on the overall migration test result found, testing laboratories could decide on a case-by-case basis if known additives and starting substances are covered by the overall migration result and no separate testing would be required for specific migration, with time and resource cost savings.
本研究旨在考察整体迁移测试程序是否也可用于测试塑料中特定物质的迁移。使用的整体迁移测试程序是与挥发性食品模拟物一起使用的蒸发重量法。对 30 种食品接触物质（添加剂和单体）进行了化学稳定性和挥发性损失测试，这些物质在整体迁移程序的加热蒸发阶段。在可接受的收率范围内确定了 18 种。结论是，在具有特定迁移限值为 5mg/kg 或更高的约 620 种欧盟物质列表中，基于稳定性和挥发性的考虑，一半以上的物质可以采用整体迁移方法进行控制。对于低固有整体迁移值的惰性塑料来说尤其如此。这意味着，基于发现的整体迁移测试结果，测试实验室可以根据具体情况决定是否已知添加剂和起始物质包含在整体迁移结果中，并且不需要进行特定迁移的单独测试，从而节省时间和资源成本。
