Constantopoulos A, Matsaniotis N
Cytobios. 1976;17(65):17-20.
The effect of bilirubin on protein kinase activity has been studied. Bilirubin inhibits the binding of cyclic AMP to protein kinase. It also inhibits the phosphorylation of histone. The inhibitory action of bilirubin is competitive, and increased amounts of cyclic AMP relieved the inhibition.
已经研究了胆红素对蛋白激酶活性的影响。胆红素抑制环磷酸腺苷(cAMP)与蛋白激酶的结合。它还抑制组蛋白的磷酸化。胆红素的抑制作用是竞争性的,增加环磷酸腺苷的量可解除这种抑制。