微囊化异烟肼在京尼平交联明胶-A-κ-卡拉胶聚电解质复合物中的应用。
Microencapsulation of isoniazid in genipin-crosslinked gelatin-A-κ-carrageenan polyelectrolyte complex.
机构信息
Department of Chemical Sciences, Tezpur University, Napaam, Assam, India.
出版信息
Drug Dev Ind Pharm. 2010 Jan;36(1):56-63. doi: 10.3109/03639040903061355.
BACKGROUND
Microspheres of gelatin-A and κ-carrageenan were prepared by using genipin, a naturally occurring crosslinker, and sunflower oil as reaction media.
METHOD
The variations in the size of the microspheres formed by varying the amount of surfactant (0.33-1.0 g/g of polymer), polymer (1.5-3.0 g), and crosslinker (0.2-0.8 mmol) were studied by scanning electron microscopy. The encapsulation of isoniazid was carried out by absorption. The isoniazid content in the prepared microspheres was determined. The release characteristic of isoniazid was also studied at pH values 1.2 and 7.4 by using UV-spectrophotometer.
RESULTS
Characterization of the isoniazid-loaded microspheres was carried out by using Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometery.
背景
明胶 A 和 κ-卡拉胶微球是通过使用京尼平，一种天然交联剂，以及葵花籽油作为反应介质制备的。
方法
通过扫描电子显微镜研究了表面活性剂（聚合物的 0.33-1.0 g/g）、聚合物（1.5-3.0 g）和交联剂（0.2-0.8 mmol）用量变化时形成的微球的粒径变化。通过吸收法包封异烟肼。测定了所制备微球中的异烟肼含量。还通过紫外分光光度计在 pH 值为 1.2 和 7.4 时研究了异烟肼的释放特性。
结果
通过傅里叶变换红外光谱、差示扫描量热法和 X 射线衍射法对载有异烟肼的微球进行了表征。
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