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肿瘤坏死因子-α抑制剂治疗期间的单纯疱疹性脑炎

Herpes simplex encephalitis during treatment with tumor necrosis factor-alpha inhibitors.

作者信息

Bradford Russell D, Pettit April C, Wright Patty W, Mulligan Mark J, Moreland Larry W, McLain David A, Gnann John W, Bloch Karen C

机构信息

Division of Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

出版信息

Clin Infect Dis. 2009 Sep 15;49(6):924-7. doi: 10.1086/605498.

DOI:10.1086/605498
PMID:19681709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3315107/
Abstract

We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described.

摘要

我们报告了3例在接受肿瘤坏死因子-α（TNF-α）抑制剂治疗风湿性疾病的患者中发生单纯疱疹病毒性脑炎的病例。尽管已有报道称TNF-α抑制剂会增加其他传染病的风险，但据我们所知，抗TNF-α药物与单纯疱疹病毒性脑炎之间的关联此前尚未见报道。

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