von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size.
作者信息
Jin S-Y, Skipwith C G, Shang D, Zheng X L
出版信息
J Thromb Haemost. 2009 Oct;7(10):1749-52. doi: 10.1111/j.1538-7836.2009.03570.x. Epub 2009 Aug 11.
Abstract
摘要
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von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size.被ADAMTS13从内皮细胞上切割下来的血管性血友病因子在大小上仍然超大。
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本文引用的文献
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Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.白细胞蛋白酶在ADAMTS13裂解位点或其附近裂解血管性血友病因子。
Blood. 2009 Aug 20;114(8):1666-74. doi: 10.1182/blood-2009-01-195461. Epub 2009 Jun 18.
2
ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals.在无血流、血小板或构象改变化学物质的情况下，ADAMTS-13可切割锚定在内皮细胞上的长型血管性血友病因子多聚体链。
J Thromb Haemost. 2009 Jan;7(1):229-32. doi: 10.1111/j.1538-7836.2008.03209.x. Epub 2008 Oct 29.
3
Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.通过编码ADAMTS13基因的慢病毒载体进行子宫内基因转移来纠正ADAMTS13缺陷。
Mol Ther. 2009 Jan;17(1):34-41. doi: 10.1038/mt.2008.223. Epub 2008 Oct 28.
4
Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress.人内皮细胞上的整合素α(v)β(3)在流体剪切应力作用下与血管性血友病因子链结合。
Blood. 2009 Feb 12;113(7):1589-97. doi: 10.1182/blood-2008-05-158584. Epub 2008 Oct 16.
5
ADAMTS13: a new link between thrombosis and inflammation.ADAMTS13：血栓形成与炎症之间的新联系。
J Exp Med. 2008 Sep 1;205(9):2065-74. doi: 10.1084/jem.20080130. Epub 2008 Aug 11.
6
Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.凝血因子VIII可加速ADAMTS13对血管性血友病因子的蛋白水解切割。
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7416-21. doi: 10.1073/pnas.0801735105. Epub 2008 May 20.
7
Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress.在流体剪切应力作用下，血小板-血管性血友病因子复合物是ADAMTS13的首选底物。
Blood. 2008 Jan 15;111(2):651-7. doi: 10.1182/blood-2007-05-093021. Epub 2007 Sep 27.
8
The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow.ADAMTS13羧基末端血小板反应蛋白1重复序列与CUB结构域之间的协同活性对于在血流状态下识别血管性血友病因子至关重要。
Blood. 2007 Sep 15;110(6):1887-94. doi: 10.1182/blood-2007-04-083329. Epub 2007 May 31.
9
Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease.外位点相互作用有助于抗血栓性ADAMTS13金属蛋白酶对血管性血友病因子的张力诱导切割。
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19099-104. doi: 10.1073/pnas.0607264104. Epub 2006 Dec 4.
10
Systemic antithrombotic effects of ADAMTS13.ADAMTS13的全身抗血栓形成作用。
J Exp Med. 2006 Mar 20;203(3):767-76. doi: 10.1084/jem.20051732. Epub 2006 Mar 13.
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