Barthélémy I, Mondié J-M
Service de chirurgie maxillofaciale et stomatologie, CHU hôtel-Dieu de Clermont-Ferrand, boulevard Léon-Malfreyt, 63058 Clermont-Ferrand cedex 1, France.
Rev Stomatol Chir Maxillofac. 2009 Sep;110(4):209-13. doi: 10.1016/j.stomax.2009.06.002. Epub 2009 Aug 13.
Giant cell tumors and pseudogiant cell tumors of the jaws are divided into cherubism, central giant cell granuloma (CGCG), aneurysmal cyst, giant cell tumor, and hyperparathyroidism-jaw tumor. These tumors have variable clinical characteristics, such as bilateral tumors in cherubism, disseminated tumors in hyperparathyroidism, or focal tumors in other types. Their radiological presentation is quite similar with presence of well-delimitated uni- or multilocular radiolucency. The primary surgical treatment must be conservative. Anatomopathology gives the histologic diagnosis, with presence of giant cells. Some tumors are locally aggressive leading to larger bone exeresis. The nosology of these giant-cell tumors remains unclear, especially for giant cell central granuloma and giant cell tumors.
颌骨巨细胞瘤和假性巨细胞瘤分为 cherubism、中央巨细胞肉芽肿(CGCG)、动脉瘤样囊肿、巨细胞瘤和甲状旁腺功能亢进-颌骨肿瘤。这些肿瘤具有不同的临床特征,例如 cherubism 中的双侧肿瘤、甲状旁腺功能亢进中的弥漫性肿瘤或其他类型中的局灶性肿瘤。它们的放射学表现非常相似,均存在边界清晰的单房或多房透光影。主要的手术治疗必须保守。解剖病理学给出组织学诊断,存在巨细胞。一些肿瘤具有局部侵袭性,导致更大范围的骨切除。这些巨细胞肿瘤的分类仍然不明确,尤其是中央巨细胞肉芽肿和巨细胞瘤。