Atkins Helen S, Spencer Stephen, Brew Simon D, Laws Thomas R, Thirlwall Rachel E, MacMillan Alastair P, Brooks Timothy J G, Simpson Andrew J H
Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.
Int J Antimicrob Agents. 2009 Nov;34(5):471-3. doi: 10.1016/j.ijantimicag.2009.06.018. Epub 2009 Aug 13.
The prophylactic potential of moxifloxacin and gatifloxacin was assessed in comparison with doxycycline, an established therapeutic antibiotic, to limit or control infection by Brucella melitensis in an experimental mouse model, determined by reduced bacterial burden in the spleen. Although moxifloxacin was found to have a small protective effect when administered 6 h following infection, neither moxifloxacin nor gatifloxacin showed significant efficacy in vivo. In comparison, doxycycline provided significant protection when prophylaxis was started at 6 h, 7 days or 14 days following infection. Overall, these results confirm the utility of doxycycline in the prophylaxis of brucellosis and suggest that neither moxifloxacin nor gatifloxacin are likely to be valuable for post-exposure prophylaxis of Brucella infection.
在一个实验小鼠模型中，通过降低脾脏中的细菌载量来确定，将莫西沙星和加替沙星的预防潜力与已确立的治疗性抗生素多西环素进行了比较，以限制或控制羊种布鲁氏菌感染。尽管发现莫西沙星在感染后6小时给药时有轻微的保护作用，但莫西沙星和加替沙星在体内均未显示出显著疗效。相比之下，当在感染后6小时、7天或14天开始预防时，多西环素提供了显著的保护作用。总体而言，这些结果证实了多西环素在预防布鲁氏菌病方面的效用，并表明莫西沙星和加替沙星都不太可能对布鲁氏菌感染的暴露后预防有价值。
