记忆表现与通过颈动脉内注射异戊巴比妥试验所确定的语言优势相关。

Memory performance is related to language dominance as determined by the intracarotid amobarbital procedure.

作者信息

Kovac S, Möddel G, Reinholz J, Alexopoulos A V, Syed T, Schuele S U, Lineweaver T, Loddenkemper T

机构信息

Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

出版信息

Epilepsy Behav. 2009 Sep;16(1):145-9. doi: 10.1016/j.yebeh.2009.07.020. Epub 2009 Aug 13.

DOI:10.1016/j.yebeh.2009.07.020

PMID:19682954

Abstract

OBJECTIVE

The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.

METHODS

In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other.

RESULTS

Language lateralization and memory lateralization were positively correlated (r=0.34, P<0.01). Correlations differed depending on the presence and type of lesion (chi(2)=7.98, P<0.05). LIs correlated significantly higher (z=2.82, P<0.05) in patients with cortical dysplasia (n=41, r=0.61, P<0.01) compared with the group without lesions (n=90, r=0.16, P>0.05), with patients with hippocampal sclerosis falling between these two groups. Both memory (P<0.01) and language (P<0.01) LIs were higher in right- compared with left-sided lesions.

CONCLUSION

Correlation of language and memory is more pronounced in patients with structural lesions as compared with patients without lesions on MRI.

摘要

目的

本研究的目的是探讨接受颈内动脉异戊巴比妥试验的癫痫患者语言与记忆偏侧化之间的关系。

方法

在386例患者中，通过偏侧化指数（LI）确定的语言偏侧化和记忆偏侧化相互关联。

结果

语言偏侧化和记忆偏侧化呈正相关（r = 0.34，P < 0.01）。相关性因病变的存在和类型而异（χ² = 7.98，P < 0.05）。与无病变组（n = 90，r = 0.16，P > 0.05）相比，皮质发育异常患者（n = 41，r = 0.61，P < 0.01）的LI相关性显著更高（z = 2.82，P < 0.05），海马硬化患者介于这两组之间。右侧病变患者的记忆（P < 0.01）和语言（P < 0.01）LI均高于左侧病变患者。