Schmidt Alexander H, Baier Daniel, Solloch Ute V, Stahr Andrea, Cereb Nezih, Wassmuth Ralf, Ehninger Gerhard, Rutt Claudia
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
Hum Immunol. 2009 Nov;70(11):895-902. doi: 10.1016/j.humimm.2009.08.006. Epub 2009 Aug 13.
Human leukocyte antigen (HLA) haplotype frequency distributions in specific populations can be applied to optimize both individual stem cell donor searches and donor registry planning. We present allele and haplotype frequencies derived from a data set of 8862 German stem cell donors who were typed at high resolution for the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genes upon registration. Calculated haplotype frequencies were used to estimate the probability p to find matching donors subject to donor registry size n. The impact of various matching standards on p(n) was analyzed. When high-resolution matching for HLA-A, HLA-B, HLA-C, and HLA-DRB1 is required, p(1,000,000) is 0.678. The corresponding value for n = 7,000,000 is 0.859. In a scenario with low-resolution matching and no consideration of HLA-C, p(1,000,000) is 0.863 and thus larger than p(7,000,000) in the scenario with stricter matching requirements. As recent findings support the importance of high-resolution matching of HLA-A, HLA-B, HLA-C, and HLA-DRB1 for outcomes of hematopoietic stem cell transplantation, our results are highly relevant for strategic planning and resource allocation of donor centers and registries.
特定人群中的人类白细胞抗原（HLA）单倍型频率分布可用于优化个体干细胞供体搜索和供体登记计划。我们展示了来自8862名德国干细胞供体数据集的等位基因和单倍型频率，这些供体在登记时对HLA - A、HLA - B、HLA - C和HLA - DRB1基因进行了高分辨率分型。计算得到的单倍型频率用于估计在供体登记规模为n的情况下找到匹配供体的概率p。分析了各种匹配标准对p(n)的影响。当要求对HLA - A、HLA - B、HLA - C和HLA - DRB1进行高分辨率匹配时，p(1,000,000)为0.678。n = 7,000,000时的相应值为0.859。在低分辨率匹配且不考虑HLA - C的情况下，p(1,000,000)为0.863，因此大于匹配要求更严格情况下的p(7,000,000)。由于最近的研究结果支持对HLA - A、HLA - B、HLA - C和HLA - DRB1进行高分辨率匹配对造血干细胞移植结果的重要性，我们的结果与供体中心和登记处的战略规划及资源分配高度相关。
