Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami Kogushi, Ube, Japan.
Atherosclerosis. 2010 Feb;208(2):366-9. doi: 10.1016/j.atherosclerosis.2009.07.036. Epub 2009 Jul 23.
Lysyl oxidase (LOX) is an enzyme critical for the stability of extracellular matrix and also known to have diverse biological functions. Little is known, however, about the role of LOX in regulating inflammation. Here we demonstrate that LOX suppresses secretion of monocyte chemoattractant protein-1 (MCP-1) in cultured vascular smooth muscle cells. Furthermore, enhancement of LOX activity reduces MCP-1 in a mouse model of abdominal aortic aneurysm (AAA), thereby preventing macrophage infiltration and AAA progression. These findings suggest that LOX has a novel function in resolving inflammation by reducing MCP-1 in AAA.
赖氨酰氧化酶（LOX）是一种对细胞外基质稳定性至关重要的酶，也具有多种生物学功能。然而，关于 LOX 在调节炎症中的作用知之甚少。在这里，我们证明 LOX 抑制培养的血管平滑肌细胞中单核细胞趋化蛋白-1（MCP-1）的分泌。此外，在腹主动脉瘤（AAA）的小鼠模型中，增强 LOX 活性可降低 MCP-1，从而防止巨噬细胞浸润和 AAA 进展。这些发现表明，LOX 通过降低 AAA 中的 MCP-1 发挥了一种新的抗炎作用。
