San Francisco VA Medical Center, San Francisco, CA 94121, USA.
J Psychiatr Res. 2010 Jan;44(1):22-31. doi: 10.1016/j.jpsychires.2009.05.011. Epub 2009 Aug 14.
Family history of psychiatric and substance use disorders has been associated with posttraumatic stress disorder (PTSD) in cross-sectional studies.
Using a prospective design, we examined the relationships of family history of psychiatric and substance use disorders to posttraumatic stress symptoms in 278 healthy police recruits. During academy training, recruits were interviewed on family and personal psychopathology, prior cumulative civilian trauma exposure, and completed self-report questionnaires on nonspecific symptoms of distress and alcohol use. Twelve months after commencement of active duty, participants completed questionnaires on critical incident exposure over the previous year, peritraumatic distress to the worst critical incident during this time, and posttraumatic stress symptoms.
A path model indicated: (1) family loading for mood and anxiety disorders had an indirect effect on posttraumatic stress symptoms at 12 months that was mediated through peritraumatic distress to the officer's self-identified worst critical incident, (2) family loading for substance use disorders also predicted posttraumatic stress symptoms at 12 months and this relationship was mediated through peritraumatic distress.
These findings support a model in which family histories of psychopathology and substance abuse are pre-existing vulnerability factors for experiencing greater peritraumatic distress to critical incident exposure which, in turn, increases the risk for development of symptoms of posttraumatic stress disorder. Replication in other first responders, military and civilians will be important to determine generalizability of these findings.
横断面研究表明,精神疾病和物质使用障碍家族史与创伤后应激障碍(PTSD)有关。
我们采用前瞻性设计,在 278 名健康警察新兵中,研究了精神疾病和物质使用障碍家族史与创伤后应激症状的关系。在学院培训期间,新兵接受了关于家庭和个人精神病理学、以前累积的平民创伤暴露情况以及非特异性痛苦和酒精使用的自我报告问卷的访谈。在开始执行任务 12 个月后,参与者完成了过去一年中关键事件暴露情况的问卷、这段时间内自己确定的最严重关键事件的创伤时痛苦程度以及创伤后应激症状的问卷。
路径模型表明:(1)心境和焦虑障碍的家族负荷对 12 个月时的创伤后应激症状有间接影响,这种影响是通过对官员自我确定的最严重关键事件的创伤时痛苦程度来介导的;(2)物质使用障碍的家族负荷也预测了 12 个月时的创伤后应激症状,这种关系是通过创伤时痛苦程度来介导的。
这些发现支持了一种模型,即精神病理学和物质滥用的家族史是经历更严重创伤时痛苦程度的先前存在的脆弱性因素,而这种痛苦程度又增加了发生创伤后应激障碍症状的风险。在其他急救人员、军人和平民中进行复制将是确定这些发现的普遍性的重要步骤。