Sundaram K S, Lev M
Department of Microbiology, CUNY Medical School, New York 10031.
Arch Biochem Biophys. 1990 Feb 15;277(1):109-13. doi: 10.1016/0003-9861(90)90557-f.
We have shown previously that the administration of warfarin to 16-day-old mice results in a significant reduction in levels of sulfatides, and to a lesser degree a reduction of other sphingolipids in brain. Vitamin K stimulates biosynthesis of sulfatides in warfarin-treated mice. We now report that warfarin inhibits brain sulfotransferase activity. This inhibition is reversed by vitamin K. The treatment of normal mice with vitamin K stimulates the activities of sulfotransferase and arylsulfatase and the turnover rate of brain sulfatides. The ability of vitamin K to influence the activity of biosynthetic and catabolic enzymes and the turnover of sulfatides suggests a possible regulatory role for vitamin K in the maturing brain.
我们之前已经表明，给16日龄小鼠服用华法林会导致脑内硫脂水平显著降低，其他鞘脂水平也有一定程度降低。维生素K可刺激经华法林处理的小鼠体内硫脂的生物合成。我们现在报告，华法林会抑制脑硫转移酶活性。这种抑制作用可被维生素K逆转。用维生素K处理正常小鼠会刺激硫转移酶和芳基硫酸酯酶的活性以及脑硫脂的周转率。维生素K影响生物合成和分解代谢酶活性以及硫脂周转率的能力表明，维生素K在成熟大脑中可能具有调节作用。
