Dutta Suvangshu, Karak Niranjan, Saikia Jyoti Prasad, Konwar Bolin Kumar
Department of Chemical Sciences, Tezpur University, Tezpur 784028, Assam, India.
Bioresour Technol. 2009 Dec;100(24):6391-7. doi: 10.1016/j.biortech.2009.06.029. Epub 2009 Aug 14.
Epoxy modified Mesua ferrea L. seed oil (MFLSO) based polyurethane nanocomposites with different weight % of clay loadings (1%, 2.5% and 5%) have been evaluated as biocompatible materials. The nanocomposites were prepared by ex situ solution technique under high mechanical shearing and ultrasonication at room temperature. The partially exfoliated nanocomposites were characterized by Fourier transform infra-red (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques. The mechanical properties such as tensile strength and scratch hardness were improved 2 and 5 times, respectively by nanocomposites formation. Even the impact resistance improved a little. The thermostability of the nanocomposites was enhanced by about 40 degrees C. Biodegradation study confirmed 5-10 fold increase in biodegradation rate for the nanocomposites compared to the pristine polymers. All the nanocomposites showed non-cytotoxicity as evident from RBC hemolysis inhibition observed in anti-hemolytic assay carried over the sterilized films. The study reveals that the epoxy modified MFLSO based polyurethane nanocomposites deserve the potential to be applicable as biomaterials.
已对具有不同粘土负载量（1%、2.5%和5%）的环氧改性铁力木种子油（MFLSO）基聚氨酯纳米复合材料作为生物相容性材料进行了评估。纳米复合材料是在室温下通过高机械剪切和超声处理的非原位溶液技术制备的。通过傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）技术对部分剥离的纳米复合材料进行了表征。纳米复合材料的形成分别使拉伸强度和划痕硬度等机械性能提高了2倍和5倍。甚至抗冲击性也略有提高。纳米复合材料的热稳定性提高了约40摄氏度。生物降解研究证实，与原始聚合物相比，纳米复合材料的生物降解率提高了5至10倍。从对灭菌薄膜进行的抗溶血试验中观察到的红细胞溶血抑制情况可以明显看出，所有纳米复合材料均显示无细胞毒性。该研究表明，环氧改性MFLSO基聚氨酯纳米复合材料有潜力作为生物材料应用。
