Hilbi Hubert
Institute of Zoology, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland.
Cell Host Microbe. 2009 Aug 20;6(2):102-4. doi: 10.1016/j.chom.2009.08.001.
Shigella flexneri and other invasive bacteria rupture the phagosome membrane and escape to the host cytoplasm. Now, Dupont et al. address the fate and signaling functions of pathogen vacuole remnants and show that these membrane fragments trigger host-cell-signaling responses, including polyubiquitination, autophagy, and pyroptosis.
福氏志贺菌和其他侵袭性细菌会破坏吞噬体膜并逃逸到宿主细胞质中。现在，杜邦等人研究了病原体液泡残余物的命运和信号功能，并表明这些膜碎片会触发宿主细胞的信号反应，包括多聚泛素化、自噬和细胞焦亡。
