Svensson Johan, Bengtsson Bengt-Ake
Department of Endocrinology, Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden.
Eur J Endocrinol. 2009 Nov;161 Suppl 1:S65-74. doi: 10.1530/EJE-09-0287. Epub 2009 Aug 14.
In adults, GH replacement therapy will often be maintained for decades. Owing to the long duration of GH replacement in many adults, it is essential to establish the long-term safety aspects of the treatment. In this review, studies that have investigated the safety profile of long-term GH replacement will be reviewed with an emphasis on studies based on data from the Pfizer International Metabolic Database (KIMS). These studies show that long-term GH replacement in adults is safe and that long-term GH replacement may even improve cardiovascular mortality and morbidity in GH-deficient adults.
在成年人中，生长激素替代疗法通常需要持续数十年。由于许多成年人的生长激素替代治疗时间较长，因此确定该治疗的长期安全性至关重要。在本综述中，将对研究长期生长激素替代安全性的研究进行综述，重点是基于辉瑞国际代谢数据库（KIMS）数据的研究。这些研究表明，成年人长期使用生长激素替代疗法是安全的，而且长期生长激素替代甚至可能改善生长激素缺乏成年人的心血管死亡率和发病率。
