从腹泻猪中分离出的产肠毒素大肠杆菌菌株的热不稳定和热稳定毒素编码基因之间几乎没有异质性。
Little heterogeneity among genes encoding heat-labile and heat-stable toxins of enterotoxigenic Escherichia coli strains isolated from diarrheal pigs.
作者信息
Zhang Chengxian, Rausch Dana, Zhang Weiping
机构信息
Department of Veterinary Science, South Dakota State University, The Center for Infectious Disease Research & Vaccinology, Brookings, South Dakota, USA.
出版信息
Appl Environ Microbiol. 2009 Oct;75(19):6402-5. doi: 10.1128/AEM.00952-09. Epub 2009 Aug 14.
Abstract
To examine whether the heat-labile enterotoxin gene in porcine enterotoxigenic Escherichia coli (ETEC) strains is as divergent as in human ETEC strains, we sequenced the heat-labile and heat-stable toxin genes from 52 and 33 porcine ETEC strains, respectively. We found that the STa gene is identical, that the LT gene has only two mutations in 4 (of 52) strains, and that both mutations cause a reduction in GM1 binding and toxicity.
摘要
为了研究猪产肠毒素大肠杆菌（ETEC）菌株中的不耐热肠毒素基因是否与人ETEC菌株中的一样具有多样性，我们分别对52株和33株猪ETEC菌株的不耐热和耐热毒素基因进行了测序。我们发现，耐热肠毒素a（STa）基因是相同的，不耐热肠毒素（LT）基因在52株中的4株中仅有两个突变，且这两个突变均导致GM1结合能力和毒性降低。
相似文献
1
Little heterogeneity among genes encoding heat-labile and heat-stable toxins of enterotoxigenic Escherichia coli strains isolated from diarrheal pigs.从腹泻猪中分离出的产肠毒素大肠杆菌菌株的热不稳定和热稳定毒素编码基因之间几乎没有异质性。
Appl Environ Microbiol. 2009 Oct;75(19):6402-5. doi: 10.1128/AEM.00952-09. Epub 2009 Aug 14.
2
Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies.猪肠致病性大肠杆菌不耐热（LT）和耐热（ST）毒素的基因融合可诱导中和抗 LT 和抗 STa 抗体。
Infect Immun. 2010 Jan;78(1):316-25. doi: 10.1128/IAI.00497-09. Epub 2009 Oct 26.
3
Relationship between heat-labile enterotoxin secretion capacity and virulence in wild type porcine-origin enterotoxigenic Escherichia coli strains.野生型猪源产肠毒素大肠杆菌菌株中热不稳定肠毒素分泌能力与毒力之间的关系。
PLoS One. 2015 Mar 13;10(3):e0117663. doi: 10.1371/journal.pone.0117663. eCollection 2015.
4
A tripartite fusion, FaeG-FedF-LT(192)A2:B, of enterotoxigenic Escherichia coli (ETEC) elicits antibodies that neutralize cholera toxin, inhibit adherence of K88 (F4) and F18 fimbriae, and protect pigs against K88ac/heat-labile toxin infection.产肠毒素大肠杆菌（ETEC）的三方融合体FaeG-FedF-LT(192)A2:B可诱导产生能中和霍乱毒素、抑制K88（F4）和F18菌毛黏附，并保护猪免受K88ac/不耐热毒素感染的抗体。
Clin Vaccine Immunol. 2011 Oct;18(10):1593-9. doi: 10.1128/CVI.05120-11. Epub 2011 Aug 3.
5
Comparison of the contributions of heat-labile enterotoxin and heat-stable enterotoxin b to the virulence of enterotoxigenic Escherichia coli in F4ac receptor-positive young pigs.热不稳定肠毒素和热稳定肠毒素b对F4ac受体阳性幼猪产肠毒素大肠杆菌毒力贡献的比较。
Infect Immun. 2008 Jul;76(7):3141-9. doi: 10.1128/IAI.01743-07. Epub 2008 Apr 21.
6
Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.表达人源或猪源肠毒素的大肠杆菌构建体在仔猪感染模型中引发相同的腹泻疾病。
Appl Environ Microbiol. 2008 Sep;74(18):5832-7. doi: 10.1128/AEM.00893-08. Epub 2008 Jul 25.
7
Genetic fusions of heat-labile toxoid (LT) and heat-stable toxin b (STb) of porcine enterotoxigenic Escherichia coli elicit protective anti-LT and anti-STb antibodies.猪产肠毒素大肠杆菌的热不稳定类毒素（LT）和热稳定毒素b（STb）的基因融合物可引发具有保护作用的抗LT和抗STb抗体。
Clin Vaccine Immunol. 2010 Aug;17(8):1223-31. doi: 10.1128/CVI.00095-10. Epub 2010 May 26.
8
Heterogeneity of Escherichia coli STb enterotoxin isolated from diseased pigs.从患病猪中分离出的大肠杆菌STb肠毒素的异质性。
J Med Microbiol. 2008 Jul;57(Pt 7):887-890. doi: 10.1099/jmm.0.2008/000281-0.
9
Virulence profiles of enterotoxigenic, shiga toxin and enteroaggregative Escherichia coli in South African pigs.南非猪中肠毒素型、志贺毒素型和肠聚集性大肠杆菌的毒力谱
Trop Anim Health Prod. 2013 Aug;45(6):1399-405. doi: 10.1007/s11250-013-0377-4. Epub 2013 Feb 17.
10
Identification of new heat-stable (STa) enterotoxin allele variants produced by human enterotoxigenic Escherichia coli (ETEC).鉴定人肠产毒性大肠杆菌（ETEC）产生的新型热稳定（STa）肠毒素等位基因变体。
Int J Med Microbiol. 2016 Nov;306(7):586-594. doi: 10.1016/j.ijmm.2016.05.016. Epub 2016 Jun 15.
引用本文的文献
1
Improvement of the Enterotoxigenic Infection Model for Post-Weaning Diarrhea by Controlling for Bacterial Adhesion, Pig Breed and Genotype.通过控制细菌黏附、猪的品种和基因型来改进断奶后腹泻的产肠毒素感染模型。
Vet Sci. 2020 Aug 7;7(3):106. doi: 10.3390/vetsci7030106.
2
Diarrheagenic Escherichia coli.致泻性大肠杆菌
Braz J Microbiol. 2016 Dec;47 Suppl 1(Suppl 1):3-30. doi: 10.1016/j.bjm.2016.10.015. Epub 2016 Nov 5.
3
Animal Enterotoxigenic Escherichia coli.动物产肠毒素大肠杆菌
EcoSal Plus. 2016 Oct;7(1). doi: 10.1128/ecosalplus.ESP-0006-2016.
4
Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors.肠产毒性大肠埃希菌不耐热毒素的等位基因变异体在全球传播，并与定植因子有关。
J Bacteriol. 2015 Jan;197(2):392-403. doi: 10.1128/JB.02050-14. Epub 2014 Nov 17.
5
Virulence repertoire of Shiga toxin-producing Escherichia coli (STEC) and enterotoxigenic Escherichia coli (ETEC) from diarrhoeic lambs of Arunachal Pradesh, India.来自印度阿鲁纳恰尔邦腹泻羔羊的产志贺毒素大肠杆菌（STEC）和产肠毒素大肠杆菌（ETEC）的毒力谱
Trop Anim Health Prod. 2011 Mar;43(3):705-10. doi: 10.1007/s11250-010-9757-1. Epub 2010 Nov 23.
本文引用的文献
1
Residues of heat-labile enterotoxin involved in bacterial cell surface binding.参与细菌细胞表面结合的热不稳定肠毒素的残基。
J Bacteriol. 2009 May;191(9):2917-25. doi: 10.1128/JB.01622-08. Epub 2009 Mar 6.
2
Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.表达人源或猪源肠毒素的大肠杆菌构建体在仔猪感染模型中引发相同的腹泻疾病。
Appl Environ Microbiol. 2008 Sep;74(18):5832-7. doi: 10.1128/AEM.00893-08. Epub 2008 Jul 25.
3
Genetic diversity of heat-labile toxin expressed by enterotoxigenic Escherichia coli strains isolated from humans.从人类分离出的产肠毒素大肠杆菌菌株所表达的不耐热毒素的遗传多样性。
J Bacteriol. 2008 Apr;190(7):2400-10. doi: 10.1128/JB.00988-07. Epub 2008 Jan 25.
4
Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.一种聚集神经节苷脂GM1分子能力降低的突变霍乱毒素的内吞作用和毒性减弱
Infect Immun. 2008 Apr;76(4):1476-84. doi: 10.1128/IAI.01286-07. Epub 2008 Jan 22.
5
Comparison of virulence gene profiles of Escherichia coli strains isolated from healthy and diarrheic swine.从健康猪和腹泻猪中分离出的大肠杆菌菌株毒力基因谱的比较。
Appl Environ Microbiol. 2006 Jul;72(7):4782-95. doi: 10.1128/AEM.02885-05.
6
Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies.用于致病性研究的添加剂模型中热稳定和热不稳定肠毒素在猪大肠杆菌病中的意义
Infect Immun. 2006 Jun;74(6):3107-14. doi: 10.1128/IAI.01338-05.
7
Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries.关于开发全细胞细菌疫苗以预防发展中国家儿童腹泻病的考量。
Vaccine. 2005 May 16;23(26):3369-85. doi: 10.1016/j.vaccine.2004.12.029.
8
Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins.在悉生仔猪模型中，一株产生多种肠毒素的产肠毒素大肠杆菌导致严重腹泻病时，不耐热肠毒素的相对重要性。
Infect Immun. 2004 Jul;72(7):3914-24. doi: 10.1128/IAI.72.7.3914-3924.2004.
9
Microbial-gut interactions in health and disease. Progress in enteric vaccine development.健康与疾病中的微生物-肠道相互作用。肠道疫苗开发进展。
Best Pract Res Clin Gastroenterol. 2004 Apr;18(2):421-45. doi: 10.1016/j.bpg.2003.11.004.
10
Enterotoxigenic Escherichia coli infections and diarrhea in a cohort of young children in Guinea-Bissau.几内亚比绍一组幼儿中的产肠毒素大肠杆菌感染与腹泻
J Infect Dis. 2002 Dec 15;186(12):1740-7. doi: 10.1086/345817. Epub 2002 Nov 18.
Zotero 插件