Key Laboratory for Animal Biotechnology of Jiangxi Province, Ministry of Agriculture of China, Jiangxi Agricultural University, 330045, Nanchang, China.
J Anim Sci. 2009 Nov;87(11):3458-63. doi: 10.2527/jas.2008-1694. Epub 2009 Aug 14.
To identify QTL for feed consumption and feeding behavior traits in pigs, ADFI, feed conversion ratio (FCR), number of visits to the feeder per day (NVD), and average feeding rate (AFR) were recorded in 577 F(2) animals from a White Duroc x Chinese Erhualian resource population during the fattening period of 120 to 240 d. A whole genome scan was performed with 183 microsatellites covering the pig genome across the entire resource population. A total of 8 QTL were identified on 5 pig chromosomes, including 3 genome-wide significant QTL for FCR on SSC2, 7, and 9, 1 significant QTL for ADFI on SSC3, and 1 for NVD on SSC7. These QTL were identified for the first time, except for the QTL for FCR on SSC2. Four of the 5 significant QTL were adjacent to the known QTL for growth, carcass, and fat deposition traits, supporting the existence of gene(s) with pleiotropic effects on these traits. White Duroc alleles were generally associated with greater phenotypic values, except for those on SSC7 and 9. Comparison of QTL for feed consumption and feeding behaviors indicated that distinct chromosomes had effects on the 2 types of traits. Characterization of causative gene(s) underlying the identified QTL would shed new light on the genetic basis of feed consumption and feeding behaviors in pigs.
为了鉴定猪的采食量和采食行为性状的 QTL，在育肥期 120 至 240 天期间，记录了 577 头大白杜洛克×中国二元杂交资源群体猪的 ADFI、饲料转化率（FCR）、每日采食次数（NVD）和平均采食率（AFR）。利用覆盖整个资源群体的 183 个微卫星对整个基因组进行了全基因组扫描。共鉴定到 8 个 QTL，分布在猪的 5 条染色体上，包括 SSC2、7 和 9 上 3 个 FCR 全基因组显著 QTL，SSC3 上 1 个 ADFI 显著 QTL，以及 SSC7 上 1 个 NVD 显著 QTL。除了 SSC2 上的 FCR QTL 外，这些 QTL 均为首次鉴定。这 5 个显著 QTL 中有 4 个与生长、胴体和脂肪沉积性状的已知 QTL 相邻，支持这些性状存在基因的多效性。大白杜洛克等位基因通常与更大的表型值相关，除了 SSC7 和 9 上的等位基因。对采食量和采食行为 QTL 的比较表明，不同的染色体对这两种性状有影响。鉴定到的 QTL 下的候选基因的特征描述将为猪的采食量和采食行为的遗传基础提供新的认识。
