Iwamoto Kazuya, Kato Tadafumi
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan.
Neuropsychobiology. 2009;60(1):5-11. doi: 10.1159/000234811. Epub 2009 Aug 14.
Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.
诸如DNA甲基化和组蛋白修饰等表观遗传改变在精神障碍的病因学或病理生理学中具有重要意义。在此，我们综述了近期关于DNA甲基化与主要精神障碍之间关系的研究。我们将重点关注DNA甲基化在有丝分裂后神经元中的作用、DNA甲基化的个体内和个体间变异、甲硫氨酸代谢途径的可能参与情况，以及与精神障碍相关的候选DNA甲基化和全基因组DNA甲基化。
