Institute of Ophthalmology, University of Catania, Catania, Italy.
Ophthalmologica. 2010;224(1):10-5. doi: 10.1159/000243765. Epub 2009 Oct 7.
To compare the efficacy of pneumatic trabeculoplasty (PNT) and argon laser trabeculoplasty (ALT) in primary open-angle glaucoma (POAG) uncontrolled with two topical therapies.
In a randomized, prospective clinical study, 32 patients received in 1 eye PNT or ALT.
At 1 month, in PNT- and in ALT-treated eyes respectively, mean intraocular pressure (IOP) decreased by 3 +/- 2.3 and 5.7 +/- 1.7 mm Hg (12.7 +/- 9.6 and 24.4 +/- 7.4%, both paired t test p < 0.001); 5 and 13 eyes (31 vs. 81%, chi(2) test p = 0.013) had an IOP reduction >or=20%, 7 and 1 eyes had an insufficient effect (IOP >20 mm Hg). Only 1 PNT-treated eye had IOP reduction >or=20% until 4 months. At 6 months, 10 ALT-treated eyes (62.5%) had IOP reduction >or=20%; 15 PNT- and 3 ALT-treated eyes had an insufficient effect (94 vs. 19%, p < 0.001). Transient anterior segment side effects, but not visual field or fundus changes, occurred after both treatments.
PNT is less effective than ALT in POAG uncontrolled with two topical therapies.
比较原发性开角型青光眼（POAG）经两种局部治疗后眼压仍不能控制的患者行气动小梁成形术（PNT）和氩激光小梁成形术（ALT）的疗效。
在一项随机前瞻性临床研究中，32 例患者的一只眼接受 PNT 或 ALT 治疗。
1 个月时，PNT 和 ALT 治疗眼的平均眼压（IOP）分别下降 3 +/- 2.3 和 5.7 +/- 1.7mmHg（12.7 +/- 9.6 和 24.4 +/- 7.4%，均配对 t 检验 P < 0.001）；IOP 降低>或=20%的眼分别为 5 只和 13 只（31%和 81%，卡方检验 P = 0.013）；IOP 降低<20%的眼分别为 7 只和 1 只（79%和 19%，卡方检验 P = 0.013）。仅有 1 只 PNT 治疗眼在 4 个月时 IOP 降低>或=20%。6 个月时，10 只 ALT 治疗眼（62.5%）IOP 降低>或=20%；15 只 PNT 治疗眼和 3 只 ALT 治疗眼疗效不佳（94%和 19%，P < 0.001）。两种治疗后均出现短暂的前段副作用，但无视野或眼底改变。
PNT 治疗 POAG 经两种局部治疗后眼压仍不能控制的疗效不如 ALT。
