盐负荷对大鼠肾皮质、髓质和乳头中腺苷酸环化酶及磷酸二酯酶活性的影响。

Effect of salt loading in the rat on adenylate cyclase and phosphodiesterase activity in kidney cortex, medulla and papilla.

作者信息

Wald H, Gutman Y, Czaczkes W

出版信息

Enzyme. 1977;22(5):336-40. doi: 10.1159/000458814.

PMID:196846

Abstract

Adenylate cyclase (AC) and phosphodiesterase (PDE) activities were studied in the cortex, medulla and papilla of the rat kidney. Sodium loading in vivo for 14 days resulted in a decrease of AC activity in the cortex, a small increase in the medulla and a substantial increase of AC activity in the papilla. Sodium loading caused reciprocal effects on PDE activity: an increase in kidney cortex and a decrease in kidney papilla. Loading of glucose in vivo or chronic administration of antidiuretic hormone in vivo did not cause the changes in AC or PDE observed after sodium loading. The possible significance of these findings is discussed.

摘要

对大鼠肾脏的皮质、髓质和乳头中的腺苷酸环化酶（AC）和磷酸二酯酶（PDE）活性进行了研究。体内钠负荷14天导致皮质中AC活性降低，髓质中略有增加，乳头中AC活性显著增加。钠负荷对PDE活性产生相反的影响：肾脏皮质中增加，肾脏乳头中减少。体内葡萄糖负荷或体内长期给予抗利尿激素不会引起钠负荷后观察到的AC或PDE变化。讨论了这些发现的可能意义。