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小型唇蛔:实验性感染小鼠中的抗体产生

Lagochilascaris minor: antibody production in experimentally infected mice.

作者信息

Prudente Mariana Félix de Souza, Crespo Adriana de Moraes Costa, Carvalhaes Mara Silvia

机构信息

Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.

出版信息

Rev Soc Bras Med Trop. 2009 May-Jun;42(3):325-8. doi: 10.1590/s0037-86822009000300016.

Abstract

Lagochilascaris minor is the causative agent of lagochilascariosis, a disease that affects the neck region and causes festering abscesses, with eggs, adult parasites and L3/L4 larvae within the purulent exudates. Today, mice are considered to be intermediate hosts for the parasite. C57BL/6 mice produce immunoglobulin IgM, IgA and IgG against the crude extract of the parasite; on the other hand, antibodies produced against the secreted/excreted antigens of Lagochilascaris minor present lower levels of IgM, IgA and IgG. This is the first description of antibody detection against different antigens of Lagochilascaris minor.

摘要

小唇蛔线虫是唇蛔线虫病的病原体,该病影响颈部区域并导致化脓性脓肿,在脓性渗出物中有虫卵、成虫寄生虫和L3/L4幼虫。如今,小鼠被认为是该寄生虫的中间宿主。C57BL/6小鼠会产生针对该寄生虫粗提物的免疫球蛋白IgM、IgA和IgG;另一方面,针对小唇蛔线虫分泌/排泄抗原产生的抗体中,IgM、IgA和IgG的水平较低。这是首次对针对小唇蛔线虫不同抗原的抗体检测进行描述。

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