Nietlispach Fabian, Leipsic Jonathon, Al-Bugami Saad, Masson Jean-Bernard, Carere Ronald G, Webb John G
Division of Interventional Cardiology, Department of Cardiology, St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia, Canada.
Swiss Med Wkly. 2009 Aug 8;139(31-32):458-62. doi: 10.4414/smw.2009.12802.
Transfemoral aortic valve implantation (TAVI) is a promising treatment modality for selected patients with severe symptomatic aortic stenosis. Peripheral access via the femoral and iliac artery is an important issue, limiting this technique's applicability in patients suffering from peripheral arterial disease. Multislice computed tomography (MSCT) reliably identifies patients with suitable peripheral access. However, MSCT involves an additional contrast dye burden in patients often suffering from renal failure. In this study, the feasibility of direct-aortic-contrast-injection for MSCT was investigated, aiming to reduce total contrast load.
Patients undergoing evaluation for TAVI underwent an aortogram including iliac and femoral arteries. In 7 selected patients with questionable peripheral access, MSCT was performed by advancing a pigtail catheter to the level of L2, followed by direct injection of 15-20 ml of contrast mixed with an equal volume of saline. This injection was followed by an injection of 40 ml of saline. Scanning was initiated 4 seconds after starting the contrast injection. All MSCT scans were obtained using a 64 slice scanner.
In all 7 patients, except one, the distal aorta, iliac and femoral arteries where adequately imaged to allow reliable assessment of peripheral access for TAVI. Of the 7 patients evaluated, 2 were rejected for TAVI based on the information of the MSCT using direct-aortic-contrast-injection. Limitations of the technique may be an underestimation of the arterial diameter due to spasms at the puncture site.
MSCT using direct-aortic-contrast-injection for assessment of peripheral access for TAVI is feasible and may provide good diagnostic images with a reduced volume of contrast.
经股动脉主动脉瓣植入术(TAVI)对于特定的有严重症状性主动脉瓣狭窄的患者而言是一种有前景的治疗方式。经股动脉和髂动脉的外周入路是一个重要问题,限制了该技术在患有外周动脉疾病患者中的应用。多层螺旋计算机断层扫描(MSCT)能够可靠地识别具有合适外周入路的患者。然而,MSCT会给常患有肾衰竭的患者带来额外的造影剂负担。在本研究中,探讨了直接主动脉造影剂注射用于MSCT的可行性,旨在减少总造影剂负荷。
接受TAVI评估的患者进行了包括髂动脉和股动脉的主动脉造影。在7例外周入路存疑的选定患者中,通过将猪尾导管推进至L2水平进行MSCT检查,随后直接注射15 - 20毫升造影剂与等量生理盐水混合液。此次注射后再注射40毫升生理盐水。在开始注射造影剂4秒后启动扫描。所有MSCT扫描均使用64层扫描仪获得。
在所有7例患者中,除1例患者外,远端主动脉、髂动脉和股动脉均得到充分成像,从而能够可靠地评估TAVI的外周入路。在评估的7例患者中,基于使用直接主动脉造影剂注射的MSCT信息,有2例患者被拒绝进行TAVI。该技术的局限性可能是由于穿刺部位痉挛导致动脉直径被低估。
使用直接主动脉造影剂注射进行MSCT以评估TAVI的外周入路是可行的,并且可能以减少的造影剂用量提供良好的诊断图像。